Organic Chemistry & Interfaces (COrInt) team Abstract This thesis work focuses on the synthesis and biological evaluation of analogues of the GSK-3 inhibitors MH-124 and CD-07 through different pharmacomodulation strategies to improve their affinity and selectivity toward the GSK-3α isoform. In the first part of this work, the introduction of a phosphorus atom within the oxazole core was investigated to reach a new family of phosphorus-containing heterocycles. Due to their moderate inhibitory pr
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